This finding establishes NET formation as a driving factor underlying endothelial dysfunction. The agents used to inhibit NET formation in this study, recombinant DNAse and Cl-amidine, have been found to be safe for patients in a Phase I trial 35 and to have no toxic effects in mouse studies Therefore, NET inhibition may prove to be a viable method for the treatment of obesity-related endothelial dysfunction and inflammation. Flegal, K. Prevalence and trends in obesity among US adults, — Wellen, K.
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Inflammation, stress, and diabetes. Joshi, M. High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation. Wong, S. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Moorthy, A. Brinkmann, V. Neutrophil extracellular traps: is immunity the second function of chromatin? Knight, J. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
Willis, V. N-alpha-benzoyl-N5- 2-chloroiminoethyl -L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. Rohrbach, A. Leshner, M. PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures.
Causey, C. The development of N-alpha- 2-carboxyl benzoyl-N 5 - 2-fluoroiminoethyl -l-ornithine amide o-F-amidine and N-alpha- 2-carboxyl benzoyl-N 5 - 2-chloroiminoethyl -l-ornithine amide o-Cl-amidine as second generation protein arginine deiminase PAD inhibitors.
Halverson, T. DNA is an antimicrobial component of neutrophil extracellular traps. Denny, M. A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. Xu, J. Extracellular histones are major mediators of death in sepsis. Fuchs, T. Extracellular DNA traps promote thrombosis.
Neutrophil extracellular trap NET impact on deep vein thrombosis.
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Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Wang, H. Obesity-induced endothelial dysfunction is prevented by deficiency of P-selectin glycoprotein ligand Demers, M. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.
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Brill, A. Neutrophil extracellular traps promote deep vein thrombosis in mice.
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Nakazawa, D. Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis. Namiki, M. Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology 22 , — Boring, L.
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Szalai, C. Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease CAD. Atherosclerosis , — Dawson, T. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Kim, C. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Clementi, A.
Singhal, A. Endothelial dysfunction: role in obesity-related disorders and the early origins of CVD. The Proceedings of the Nutrition Society 64 , 15—22 Smith, C. News Ticker. Big Brother big brother 21 Christie Murphy jessica milagros live feeds.
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